256. ROZHOVORY

 

Krystalografická společnost 
Regionální komitét českých a slovenských krystalografů
Ústav makromolekulární chemie AV ČR

Inhibition of Serine and Aspartic Proteases

Čas:

pondělí 25. 11. 2002, začátek ve 13.00

Místo:

Ústav makromolekulární chemie AV ČR, posluchárna B

Doprava:

Konečná tramvají 1, 2, 18 na Petřinách.

 

 

Topics: 
X-ray diffraction, molecular modeling and dynamic studies of enzymatic reactions, inhibition of HIV protease, drug design, theoretical analysis of enzymatic reactions, protein crystallography 

Program:

13.00-13.30

Jindřich Hašek (Inst.of Macromolecular Chemistry, Acad.Sci., Praha, CZ) 
Complex Study of HIV proteases

13.30-14.00

Mariusz Jaskolski (Poznan, PL) 
Atomic Resolution Structures of Trypsin Inhibitors

14.00-14.30

Grzegorz Bujacz, Natasza Ziolkowska (Technical University, Lodz, PL) 
Structural investigation of HIV-1 protease inhibitors

14.30-15.00

Jiri Brynda (Inst.of Molecular Genetics, Acad.Sci., Praha, CZ)
High Resolution Structure of HIV1 Protease – Inhibitor Komplex

15.00-15.30 Break 

15.30-15.50

Tereza Skalova (Inst.of Macromolecular Chemistry, Acad.Sci., Praha, CZ) 
Structural and Energy Comparison of Ethyleneamine Inhibitor Binding 
to the Wild and Mutant HIV Proteases

15.50-16.10

Karel Zimmermann (INRA Paris) 
Soft Block Constraints in Energy Minimization – HIV protease experiments

16.10-16.30

Eva Buchtelova (Inst.of Macromolecular Chemistry, Acad.Sci.,Praha, CZ) 
Product of Autoproteolytic Cleavage Found in the Active Site of HIV Protease by X-ray Crystallography

16.30-16.50

Jiří Dybal, Karel Huml, Martin Kabeláč, Tomáš Reschel, Karel Ulbrich (Inst.of Macromolecular Chemistry, Inst.Phys.Chem., Acad.Sci.,Praha, CZ)
Computer Model of DNA B - poly(L-lysine) Interaction

16.50-17.00

Discussion

There is no fee and no preliminary registration is required. However, if you like to be informed about the program changes or to receive written materials or have your own contribution to the seminar, please send a short message to address hasek@imc.cas.cz

Abstracts or written records of lectures are welcomed. Contributions under 500 words will be considered as abstracts and published as they are. Longer contributions will pass standards reviewing procedure in the journal.

Abstracts of lectures will be published in 2003 in the journal Materials Structure, ISSN 1211-5894, Vol.10, no.1, 2003.